What is Crestor?

Crestor is original rosuvastatin drug manufactured by AstraZeneca. It lowers "bad" LDL cholesterol and increases "good" HDL, and stronger than other statins. Doctors prescribe pills Crestor to people who have high risk of cardiovascular catastrophe, to protect them from a heart attack, and ischemic stroke. In studies of rosuvastatin was attended by many thousands of patients. All of them prescribed the original drug Crestor. Pills rosuvastatin competing firms have a weaker evidence base, but are cheaper. All concerned about medication side effects Crestor and other statins. Below explained in detail what they are, how to alleviate or remove entirely. Read also the instructions for use, written in accessible language. Learn the indications, contraindications, dosages, the regimen.Crestor reduces "bad" LDL cholesterol in the blood, partially blocking its production in the liver. Also reduces the concentration of triglycerides, apolipoprotein b, lipoprotein very low density (VLDL). Increases "good" HDL cholesterol. Reduces chronic indolent inflammation in the blood vessels. Improves the performance of C-reactive protein and other markers of inflammation. The results of the blood tests begin to improve in 1-2 weeks, maximum effect in 2-4 weeks.

Crestor (Rosuvastatin) General Information

Crestor (Rosuvastatin) is a statin-induced hypolipidemic drug designed to reduce the production of "bad" and increase the concentration of "good" cholesterol in the blood plasma. The drug of the last (fourth) generation is effectively used in the treatment of hypercholesterolemia and for the prevention of atherosclerosis and its consequences.

Cleaning the blood vessels and preventing the formation of atherosclerotic plaques, it inhibits the development of infarction and ischemic stroke in patients with high cardiovascular risk. Rosuvastatin is one of the most studied drugs in the statin group - its effectiveness has been proven experimentally on 170,000 volunteers.

Method of application and dose:

The drug is prescribed inside at any time of the day regardless of the meal. The tablet should be swallowed whole with water without chewing or crushing. Before the start of drug therapy Crestor® patient is required to begin to comply with the standard hypolipidemic diet and continue to observe her during treatment. The dose should be selected individually depending on indications and therapeutic response, taking into account the current recommendations for target levels of lipids. Patients with renal insufficiency mild or moderate severity dose adjustment is not required. Patients with moderate renal impairment, the recommended initial dose of the drug 5 mg.

Composition:

Crestor 5 mg:

Biconvex; 5 mg each: round, yellow, engraved with "ZD4522 5" on either side. Inactive substances: lactose monohydrate, microcrystalline cellulose, calciumphosphate, magnesium stearate, crospovidone, glycerol triacetate, hypromellose, iron oxide red (E172), titanium dioxide, purified water.

Crestor 10 mg:

10 mg each: round, pink, engraved "ZD4522 10" on either side. Inactive substances: lactose monohydrate, microcrystalline cellulose, calcium phosphate, magnesium stearate, crospovidone, glycerol triacetate, hypromellose, iron oxide red (E 172), titanium dioxide, purified water.

Crestor 20 mg:

20 mg each: round, pink, engraved "ZD4522 20" on either side. Inactive substances: lactose monohydrate, microcrystalline cellulose, calcium phosphate, magnesium stearate, crospovidone, glycerol triacetate, hypromellose, iron oxide red (E 172), titanium dioxide, purified water.

More info about dosages and shipping options you can find on the Pharmacy website

Crestor 5 mg

Crestor 10 mg

Crestor 20 mg

When Do You Need to Use Crestor (Rosuvastatin)?

The uniqueness of the latest generation of statin is that it is used with an elevated C-reactive protein. It is this indicator, rather than NSAIDs and NPLP, that provides a reliable picture of vascular risks. In small, in comparison with other statin dosages, the drug more actively normalizes the lipid balance.

Excessive reduction in the production of harmful cholesterol leads to depressive states, loss of memory, a reduction in life, so it is important to monitor the rate of cholesterol. Patients of adulthood, as well as patients with renal and hepatic dysfunction, do not have special recommendations for dosage.

Rosuvastatin is a fourth-generation drug with an extended spectrum of effects. It is used in the following pathologies:

  1. Hypercholesterolemia, characterized by increased plasma concentrations of cholesterol;
  2. Hypertriglyceridemia due to high triglycerol;
  3. Homozygous hypercholesterolemia of genetic nature;
  4. Prevention of the consequences of atherosclerosis - hypertension, ischemic heart disease, cerebral stroke in patients of mature (after 50) age.

How Does Rosuvastatin Work?

The active component of the drug has a hypolipidemic effect. Rosuvastatin inhibits the enzyme HMG-CoA-reductase, responsible for the production of mevalonate - the precursor of cholesterol. The agent acts directly on the hepatocytes (liver cells) responsible for the production of its own (endogenous) cholesterol. Increasing the number of low-density lipoprotein receptors on the surface of hepatocides, it activates the removal of excess cholesterol from the circulatory system. The preparation stimulates the synthesis of nitrogen.

An important difference between Rosuvastatin and other statins is that it not only fights against "bad" cholesterol, but also reduces chronic inflammation, which, according to many scientists, is the main cause of atherosclerosis. The drug stimulates the synthesis of nitrogen, contributing to the relaxation of blood vessels, and creates a so-called pleiotropic (additional) effect.

After using the statin, the active ingredient quickly, though not completely, enters the circulatory system, evenly distributed throughout the tissues of the body. It is absorbed more slowly than its analogues and the period of excretion is longer. The maximum plasma concentration of the active ingredient is observed after 5 hours after use.

Which Dosage of Rosuvastatin Should You Take?

Rosuvastatin is taken inside (regardless of food intake, at any time of the day). Do not grind and not chew, swallow it, washed down with water. The initial dose is 1 time per day 10 mg; it is possible to increase the dose at 4 weeks to 20 mg. An increase in the dose to 40 mg is possible only under medical supervision in patients with severe familial homozygous hypercholesterolemia with a high risk of developing cardiovascular complications that did not achieve the desired result with 20 mg of the drug.

Patients who have risk factors for myopathy, the initial dose is 5 mg. When used with gemfibrazilom dose of rosuvastatin should not be more than 10 mg / day. With mild or moderate renal failure, as well as in elderly patients, dose adjustments are not required.

Before the treatment and throughout the period of therapy with rosuvastatin, a standard lipid-lowering diet should be followed. When treating every 2-4 weeks, it is necessary to monitor the lipid profile and, if necessary, adjust the dose of rosuvastatin. A dose of 40 mg is contraindicated in patients who have risk factors for rhabdomyolysis (familial or personal history of muscular disease, hypothyroidism, mean renal insufficiency (creatinine clearance less than 60 ml / min), alcohol abuse, myotoxicity when taking fibrates or other inhibitors of HMG-CoA reductase, patients of the Asian race, simultaneous reception of fibrates, conditions that are accompanied by an increase in the content of the drug in the systemic circulation). Patients who take 40 mg of the drug are recommended to monitor the indicators of the functional state of the kidneys.

Who Mustn't Take the Drug: Contraindications

  • Hypersensitivity,
  • expressed violations of the functional state of the kidneys (creatinine clearance less than 30 ml / min),
  • liver disease in the active phase (including a persistent increase in liver transaminase activity),
  • myopathy,
  • joint administration of cyclosporine,
  • lactation/pregnancy,
  • age 18 years (safety and efficacy not established),
  • women of reproductive age who do not use reliable contraceptives.

Possible Side Effects of Rosuvastatin

  1. Nervous system: headache, asthenic syndrome, dizziness, anxiety, insomnia, depression, paresthesia, neuralgia; digestive system: constipation, abdominal pain, nausea, reversible dose-dependent transient increase in liver transaminase activity, gastritis, dyspepsia (including diarrhea, flatulence, vomiting), gastroenteritis;
  2. Respiratory system: pharyngitis, sinusitis, rhinitis, bronchitis, bronchial asthma, dyspnea, cough, pneumonia;
  3. Circulatory system: stenocardia, palpitation, increased blood pressure, vasodilation; system of support and movement: myalgia, arthralgia, muscular hypertonus, arthritis, back pain, myopathy, pathological limb fracture, rhabdomyolysis (together with impaired renal functional status, with taking 40 mg of the drug);
  4. Genitourinary system: tubular proteinuria, peripheral edema, urinary tract infections, abdominal pain;
  5. Allergic reactions: itching, skin rash, angioedema;
  6. Other: anemia, accidental trauma, chest pain, ecchymosis, diabetes mellitus, periodontal abscess, flu-like syndrome.

Crestor Side Effects:

Pills Crestor, like other statins, can cause muscle pain, weakness, fatigue, impaired memory and thinking, skin rashes, digestive disorders. Take a look at "Side effects of statins" — learn how to relieve uncomfortable symptoms or remove them entirely. Rosuvastatin drugs have particular side effects. Read more, how safe is rosuvastatin. People who have a high risk of heart attack and stroke, Crestor does more good than harm. To cancel this medicine should only be made if the side effects intolerable and facilitate them does not work. The danger of liver problems is exaggerated. Don't worry about them, if you do not abuse alcohol. Side effects observed while taking the drug Crestor®, usually expressed slightly and are themselves. Virtually all drugs have side effects. Typically, this occurs when the medication in maximum doses, when you use drugs over a long period of time, while taking several medications. And possible individual intolerance of a particular substance. It can harm the body, so if a drug is causing you side effects, it is necessary to stop its intake and consult a doctor.

Crestor (Rosuvastatin) Drug Interactions

  • When interacting with drugs of nicotinic acid, the risk of manifestation of renal insufficiency, as well as rhabdomyolysis, increases;
  • With diuretics, the risk of lowering the level of endogenous steroid hormones increases;
  • When interacting with additional lipid-lowering agents, the likelihood of multiple side effects increases;
  • With cardiac glycosides, the concentration of digoxin increases;
  • When interacting with immunosuppressants, the probability of developing acute renal failure increases, as well as rhabdomyolysis;
  • When interacting with anticoagulants, the probability of bleeding increases;
  • With antifungal agents increases the likelihood of developing acute renal failure, as well as rhabdomyolysis;
  • With alcohol, the risk of liver damage increases - therefore, it should be as limited as possible.

Comment

 

Laura Bladon 22:19:55 10/11/18

Six months ago, my husband found high cholesterol in the blood. We can say that at that time he just went off scale, and her husband was prescribed a special diet and was prescribed Crestor at a dose of 10 mg, after a month the dose was increased to 20 mg. Of course, I was horrified by the number and seriousness of the side effects prescribed in the instructions, but my husband took it more calmly, and without objection he began to drink pills and follow the diet. As shown by recent tests, cholesterol has fallen well in six months, although it has not gone up to normal. This, of course, pleased, but unfortunately, it didn’t work without consequences: the husband suffers from constant constipation, does not sleep well, gets tired quickly. However, he does not intend to refuse Crestor, he believes that the drug is excellent, and he says that constipation is better than a stroke.


Sergio Rogliano 19:45:47 25/09/18

Crestor is an excellent drug from all statins. With evidence base. After 1.5-2 months of continuous admission, the results are visible. Assigned 1 time per day, the dosage is selected individually, while taking the drug control lipid spectrum of blood, ALT, AST.


Alexander Connell 15:35:27 03/07/18

About five years ago I began to struggle with excess weight. I went in for sports, brought the food back to normal and in a couple of years came close to normal weight - to my 80 kg. But the level of cholesterol at the same time practically did not decrease. Therefore, the doctor prescribed me a Crestor. He drank it for two months. By the end of the first level began to fall. By the end of the second went back to normal. After discontinuation of the drug, cholesterol went up again. After the consultation, the doctor prescribed a repeated long course. All anything, but painfully expensive drug is obtained. I decided to do a little research and found out that the Crestor counterparts, even if they are not very expensive, have the same effect, so I started buying Rosuvastatin. The result after the application is exactly the same as that of the cross, I did not observe any side effects.


Michael Gardner 00:01:29 20/02/18

Crestor today is my salvation. I've been taking it for about a year. Later this time I can judge its action and efficiency. My tests are getting a lot better. Sugar is almost normal, lipid profile as well. The doctor prescribed Crestor speaks very highly of him and says that today, Crestor best statin. Yes, he more expensive than their counterparts, but it works Crestor better than analogs.


Russell Darrow 10:10:50 15/01/18

I have genetically high cholesterol. One day, my cholesterol went up to 342. For 2 months, he took 10 mg of Crestor, and the cholesterol level fell to 154. I was happy, stopped drinking pills, started eating delicious... and my cholesterol went back to 266. Thus, I had to return to the reception of Crestor to keep your cholesterol within reasonable limits.


Lena 23:56:29 08/10/17

The doctor prescribes and always solves the patient. You already had a heart problem and dose of crestor is above average, so of course it is better to take crestor. But if you're not solvent, you have to take at least some statin. You can use the trail. scheme. Take crestor 20 mg for as long as the cholesterol and lipid profile is not coming to target values and your cardiologist will tell you that your tests were all fine. Only after that try to switch to analog.But always remember that human life is priceless! Better once a month to give up going to the grocery store or not to buy that kind of thing, but to buy important drug and live!


Jacky Black 00:01:29 08/07/17

Best drug all of the statins. Quickly stabilizes the cholesterol level to the target level. In contrast to its predecessors, the therapeutic effect even at low doses.


Danis Jons 23:59:52 22/12/16

Take Crestor 20 mg. in 1.5 month of taking cholesterol fell from 6.5 to 3.3.


Jessica B. 18:49:49 15/10/16

Crestor is a great drug from all statins. With the evidence base. After 1.5 - 2 months of admission, the results are visible. Is appointed 1 time a day, the dosage is selected individually, while taking the drug, control lipid profile, ALT, AST.


Victoria 22:24:38 09/07/16

Crestor today is my salvation. Taking it for about a year. After this time you can judge his action and efficiency. My tests are much better. Sugar is almost normal, lipid profile as well. The doctor prescribed Crestor speaks very highly of him and says that today, Crestor best statin. Yes, he more expensive than their counterparts, but it works Crestor better than analogs. And to save you need to buy a big package, so naturally it is cheaper.